Table 2.
Characteristics of participants providing individual participant data (categorical variables)
| Trial | Gender | Epilepsy type | Epilepsy type reclassifiedc | ||||||
| Male | Female | Missing | Genb | Partial | Missing | Genb | Partial | Unclassifiedd | |
| Banu 2007 | 61 (56%) | 47 (44%) | 0 (0%) | 49 (45%) | 59 (55%) | 0 (0%) | 49 (45%) | 59 (55%) | 0 (0%) |
| Baulac 2012 | 347 (60%) | 236 (40%) | 0 (0%) | 0 (0%) | 583 (100%) | 0 (0%) | 0 (0%) | 583 (100%) | 0 (0%) |
| Bill 1997 | 174 (61%) | 113 (39%) | 0 (0%) | 105 (37%) | 182 (63%) | 0 (0%) | 75 (26%) | 182 (63%) | 30 (10%) |
| Biton 2001 | 60 (44%) | 75 (55%) | 1 (1%) | 46 (34%) | 82 (60%) | 8 (6%) | 33 (24%) | 82 (60%) | 21 (15%) |
| Brodie 1995a | 56 (41%) | 80 (59%) | 0 (0%) | 54 (40%) | 82 (60%) | 0 (0%) | 34 (25%) | 82 (60%) | 20 (15%) |
| Brodie 1995b | 56 (45%) | 68 (55%) | 0 (0%) | 62 (50%) | 62 (50%) | 0 (0%) | 39 (31%) | 62 (50%) | 23 (19%) |
| Brodie 1999 | 83 (55%) | 67 (45%) | 0 (0%) | 45 (30%) | 105 (70%) | 0 (0%) | 0 (0%) | 105 (70%) | 45 (30%) |
| Brodie 2007 | 319 (55%) | 260 (45%) | 0 (0%) | 113 (20%) | 466 (80%) | 0 (0%) | 50 (9%) | 466 (80%) | 63 (11%) |
| Chadwick 1998 | 157 (54%) | 135 (46%) | 0 (0%) | 0 (0%) | 292 (100%) | 0 (0%) | 0 (0%) | 292 (100%) | 0 (0%) |
| Craig 1994 | 71 (43%) | 92 (55%) | 3 (2%) | 86 (52%) | 80 (48%) | 0 (0%) | 2 (1%) | 80 (48%) | 84 (51%) |
| de Silva 1996 | 86 (50%) | 81 (47%) | 6 (3%) | 84 (49%) | 89 (51%) | 0 (0%) | 84 (49%) | 89 (51%) | 0 (0%) |
| Dizdarer 2000 | 21 (40%) | 31 (60%) | 0 (0%) | 0 (0%) | 52 (100%) | 0 (0%) | 0 (0%) | 52 (100%) | 0 (0%) |
| Eun 2012 | 48 (57%) | 36 (43%) | 0 (0%) | 0 (0%) | 84 (100%) | 0 (0%) | 0 (0%) | 84 (100%) | 0 (0%) |
| Guerreiro 1997 | 100 (52%) | 93 (48%) | 0 (0%) | 50 (26%) | 143 (74%) | 0 (0%) | 45 (23%) | 143 (74%) | 5 (3%) |
| Heller 1995 | 117 (48%) | 126 (52%) | 0 (0%) | 141 (58%) | 102 (42%) | 0 (0%) | 82 (34%) | 102 (42%) | 59 (24%) |
| Kwan 2009 | 40 (49%) | 41 (51%) | 0 (0%) | 48 (59%) | 29 (36%) | 4 (5%) | 25 (31%) | 29 (36%) | 27 (33%) |
| Lee 2011 | 57 (52%) | 53 (48%) | 0 (0%) | 15 (14%) | 95 (86%) | 0 (0%) | 6 (5%) | 95 (86%) | 9 (8%) |
| Mattson 1985 | 413 (87%) | 58 (12%) | 4 (1%) | 1 (0%) | 474 (100%) | 0 (0%) | 1 (0%) | 474 (100%) | 0 (0%) |
| Mattson 1992 | 445 (93%) | 35 (7%) | 0 (0%) | 0 (0%) | 480 (100%) | 0 (0%) | 0 (0%) | 480 (100%) | 0 (0%) |
| Nieto‐Barrera 2001 | 329 (53%) | 293 (47%) | 0 (0%) | 3 (1%) | 619 (99%) | 0 (0%) | 1 (0%) | 619 (100%) | 2 (0%) |
| Ogunrin 2005 | 34 (62%) | 21 (38%) | 0 (0%) | 45 (82%) | 10 (18%) | 0 (0%) | 26 (47%) | 10 (18%) | 19 (35%) |
| Pal 1998 | 47 (50%) | 45 (48%) | 2 (2%) | 34 (36%) | 60 (64%) | 0 (0%) | 34 (36%) | 60 (64%) | 0 (0%) |
| Placencia 1993 | 67 (35%) | 125 (65%) | 0 (0%) | 59 (31%) | 133 (69%) | 0 (0%) | 35 (18%) | 133 (69%) | 24 (13%) |
|
Privitera 2003 (CBZ branch)a |
215 (54%) | 180 (46%) | 0 (0%) | 88 (22%) | 285 (72%) | 22 (6%) | 51 (13%) | 285 (72%) | 59 (15%) |
|
Privitera 2003 (VPS branch)a |
112 (50%) | 113 (50%) | 0 (0%) | 131 (58%) | 78 (35%) | 16 (7%) | 86 (38%) | 78 (35%) | 61 (27%) |
| Ramsey 1992 | 73 (54%) | 63 (46%) | 0 (0%) | 136 (100%) | 0 (0%) | 0 (0%) | 110 (81%) | 0 (0%) | 26 (19%) |
| Ramsey 2010 | 126 (48%) | 135 (52%) | 0 (0%) | 150 (57%) | 53 (20%) | 58 (22%) | 80 (31%) | 53 (20%) | 128 (49%) |
| Reunanen 1996 | 188 (54%) | 163 (46%) | 0 (0%) | 114 (32%) | 237 (68%) | 0 (0%) | 71 (20%) | 237 (68%) | 43 (12%) |
| Richens 1994 | 153 (51%) | 147 (49%) | 0 (0%) | 154 (51%) | 146 (49%) | 0 (0%) | 87 (29%) | 146 (49%) | 67 (22%) |
| SANAD A 2007 | 922 (54%) | 755 (44%) | 44 (3%) | 25 (1%) | 1491 (87%) | 205 (12%) | 16 (1%) | 1491 (87%) | 214 (12%) |
| SANAD B 2007 | 420 (59%) | 282 (39%) | 14 (2%) | 463 (65%) | 52 (7%) | 201 (28%) | 397 (55%) | 52 (7%) | 267 (37%) |
| Steiner 1999 | 101 (56%) | 80 (44%) | 0 (0%) | 91 (50%) | 90 (50%) | 0 (0%) | 55 (30%) | 90 (50%) | 36 (20%) |
| Stephen 2007 | 114 (50%) | 112 (49%) | 1 (0%) | 32 (14%) | 154 (68%) | 41 (18%) | 29 (13%) | 154 (68%) | 44 (19%) |
|
Trinka 2013 (CBZ branch)a |
551 (55%) | 448 (45%) | 0 (0%) | 141 (14%) | 858 (86%) | 0 (0%) | 48 (5%) | 858 (86%) | 93 (9%) |
|
Trinka 2013 (VPS branch)a |
398 (57%) | 305 (43%) | 0 (0%) | 513 (73%) | 190 (27%) | 0 (0%) | 285 (41%) | 190 (27%) | 228 (32%) |
| Turnbull 1985 | 73 (52%) | 67 (48%) | 0 (0%) | 77 (55%) | 63 (45%) | 0 (0%) | 42 (30%) | 63 (45%) | 35 (25%) |
| Verity 1995 | 122 (47%) | 138 (53%) | 0 (0%) | 152 (58%) | 108 (42%) | 0 (0%) | 152 (58%) | 108 (42%) | 0 (0%) |
| Werhahn 2015 | 215 (60%) | 146 (40%) | 0 (0%) | 0 (0%) | 361 (100%) | 0 (0%) | 0 (0%) | 361 (100%) | 0 (0%) |
| Total | 6971(56%) | 5345 (43%) | 75 (1%) | 3307 (27%) | 8529 (69%) | 555 (4%) | 2130 (17%) | 8529 (69%) | 1732 (14%) |
aTrials designed in two strata based on whether recommended treatment would be CBZ or VPS. Within the two strata, participants were randomised to TPM in Privitera 2003/LEV in Trinka 2013 or CBZ/VPS depending on the strata. Data analysed according to the separate strata (CBZ branch or VPS branch) in this review. bGen: Generalised tonic‐clonic seizures with or without other seizure types cSee Sensitivity analysis for further details of misclassification of epilepsy type dUnclassified seizures defined as missing seizure type or generalised onset seizures and age of onset of seizures over the age of 30 years (see Sensitivity analysis for further details)