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. 2017 Jun 29;2017(6):CD011412. doi: 10.1002/14651858.CD011412.pub2

Table 6.

Number of participants contributing individual participant data to analyses

Trial Time to withdrawal from allocated treatmentc Time to first seizure Time to 12‐month remissiond Time to six‐month remissiond
Cens Event Total Missing Cens Event Total Missing Cens Event Total Missing Cens Event Total Missing
Banu 2007a 0 0 0 108 39 69 108 0 0 0 0 108 0 0 0 108
Baulac 2012 392 191 583 0 388 186 574 9 251 323 574 9 194 380 574 9
Bill 1997 232 55 287 0 137 145 282 5 190 92 282 5 136 146 282 5
Biton 2001 99 36 135 1 64 71 135 1 0 0 0 136 90 45 135 1
Brodie 1995a 78 58 136 0 69 67 136 0 0 0 0 136 122 14 136 0
Brodie 1995b 79 45 124 0 52 72 124 0 0 0 0 124 96 28 124 0
Brodie 1999 95 55 150 0 70 80 150 0 0 0 0 150 106 44 150 0
Brodie 2007 323 256 579 0 350 229 579 0 260 319 579 0 177 402 579 0
Chadwick 1998 69 223 292 0 102 190 292 0 0 0 0 292 193 99 292 0
Craig 1994 0 0 0 166 68 81 149 17 117 30 147 19 58 89 147 19
de Silva 1996 100 67 167 6 18 149 167 6 22 145 167 6 19 148 167 6
Dizdarer 2000 44 8 52 0 40 12 52 0 11 41 52 0 8 44 52 0
Eun 2012 75 9 84 0 52 32 84 0 0 0 0 84 35 49 84 0
Guerreiro 1997 151 42 193 0 106 84 190 3 112 78 190 3 84 106 190 3
Heller 1995 166 77 243 0 66 177 243 0 78 165 243 0 49 194 243 0
Kwan 2009 60 21 81 0 38 29 67 14 68 13 81 0 30 50 80 1
Lee 2011 73 37 110 0 79 31 110 0 0 0 0 110 39 71 110 0
Mattson 1985 267 208 475 0 226 238 464 11 325 149 474 1 281 193 474 1
Mattson 1992 308 172 480 0 165 303 468 12 334 133 467 13 242 225 467 13
Nieto‐Barrera 2001 511 111 622 0 310 312 622 0 0 0 0 622 431 191 622 0
Ogunrin 2005a 0 0 0 55 29 26 55 0 0 0 0 55 0 0 0 55
Pal 1998 0 0 0 94 41 49 90 4 82 8 90 4 63 27 90 4
Placencia 1993 158 32 190 2 121 71 192 0 132 60 192 0 69 123 192 0
Privitera 2003
(CBZ branch)b 		221 174 395 0 208 187 395 0 316 79 395 0 194 201 395 0
Privitera 2003
(VPS branch)b 		111 114 225 0 119 106 225 0 180 45 225 0 106 119 225 0
Ramsey 1992 113 23 136 0 81 44 125 11 0 0 0 136 78 47 125 11
Ramsey 2010 192 69 261 0 197 64 261 0 0 0 0 261 0 0 0 261
Reunanen 1996 288 63 351 0 216 135 351 0 0 0 0 351 328 23 351 0
Richens 1994 210 76 286 14 91 199 290 10 92 198 290 10 77 213 290 10
SANAD A 2007 857 815 1672 49 383 1261 1644 77 577 1067 1644 77 355 1326 1681 40
SANAD B 2007 400 299 699 17 182 511 693 23 167 526 693 23 96 610 706 10
Steiner 1999 108 73 181 0 100 81 181 0 0 0 0 181 157 24 181 0
Stephen 2007 160 67 227 0 81 140 221 6 172 55 227 0 137 90 227 0
Trinka 2013
(CBZ branch)b 		760 239 999 0 572 427 999 0 780 219 999 0 336 663 999 0
Trinka 2013
(VPS branch)b 		583 120 703 0 456 247 703 0 484 219 703 0 191 512 703 0
Turnbull 1985 91 49 140 0 75 65 140 0 47 93 140 0 36 104 140 0
Verity 1995 187 59 246 14 59 187 246 14 84 162 246 14 19 227 246 14
Werhahn 2015 195 166 361 0 249 96 345 16 211 150 361 0 178 183 361 0
Total 7756 4109 11,865 526 5699 6453 12,152 239 5092 4369 9461 2930 4810 7010 11,820 571

Abbreviation: cens = censored

aFor two studies we could only calculate 'Time to first seizure'; the study duration of Ogunrin 2005 was 12 weeks, and all randomised participants completed the study without withdrawing; and Banu 2007 did not record the dates of all seizures after randomisation and dates of withdrawal for allocated treatment for all participants. bTrials designed in two strata based on whether recommended treatment would be CBZ or VPS. Within the two strata, participants were randomised to TPM in Privitera 2003/LEV in Trinka 2013 or CBZ/VPS depending on the strata. Data analysed according to the separate strata (CBZ branch or VPS branch) in this review. cWithdrawal information was not available for two trials so we could not calculate 'Time to withdrawal of allocated treatment' (Craig 1994; Pal 1998). dWe could not calculate 'Time to 12‐month remission' for nine trials as the duration of the study was less than 12 months (Biton 2001; Brodie 1995a; Brodie 1995b; Chadwick 1998; Eun 2012; Lee 2011; Ramsey 1992; Reunanen 1996; Steiner 1999) and we could not calculate 'Time to 12‐month remission' or 'Time to six‐month remission' for three trials as the duration of the study was less than six months (Brodie 1999; Nieto‐Barrera 2001; Ramsey 2010).