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. 2017 Jun 29;2017(6):CD011412. doi: 10.1002/14651858.CD011412.pub2
Methods Prospective quasi‐randomised, open‐label trial conducted at a single hospital in Turkey
2 treatment arms: CBZ and OXC
Participants Children with partial epilepsy (not stated how many were newly diagnosed)
Number randomised: CBZ = 26, OXC = 26
21 boys (40%)
100% of participants had partial epilepsy
Mean age (range): 11 (4‐15 years)
Interventions Monotherapy with CBZ or OXC
CBZ prescribed at 20‐25 mg/kg/d and OXC at 30‐50 mg/kg/d
Range of follow‐up: 3.5 to 26 months
Outcomes Seizure recurrence
Most common side effects
Number of participants switching treatment
Notes IPD provided for all outcomes of this review by trial author. Trial publication available as abstract only, additional data provided by trial authors
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Quasi‐randomisation by alternately allocating participants to CBZ or OXC (information provided by trial authors)
Allocation concealment (selection bias) High risk Allocation was not concealed (alternate allocation)
Blinding of participants and personnel (performance bias) All outcomes High risk Open‐ label trial
Blinding of outcome assessment (detection bias) All outcomes High risk Open‐ label trial
Incomplete outcome data (attrition bias) All outcomes Low risk Attrition rates reported, ITT approach, all randomised participants analysed from IPD provided (see footnote 2)
Selective reporting (reporting bias) Low risk All outcomes reported or calculated with IPD provided (see footnote 2)
Other bias Low risk None identified