Methods | Prospective quasi‐randomised, open‐label trial conducted at a single hospital in Turkey 2 treatment arms: CBZ and OXC |
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Participants | Children with partial epilepsy (not stated how many were newly diagnosed) Number randomised: CBZ = 26, OXC = 26 21 boys (40%) 100% of participants had partial epilepsy Mean age (range): 11 (4‐15 years) |
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Interventions | Monotherapy with CBZ or OXC CBZ prescribed at 20‐25 mg/kg/d and OXC at 30‐50 mg/kg/d Range of follow‐up: 3.5 to 26 months |
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Outcomes | Seizure recurrence Most common side effects Number of participants switching treatment |
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Notes | IPD provided for all outcomes of this review by trial author. Trial publication available as abstract only, additional data provided by trial authors | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | Quasi‐randomisation by alternately allocating participants to CBZ or OXC (information provided by trial authors) |
Allocation concealment (selection bias) | High risk | Allocation was not concealed (alternate allocation) |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Open‐ label trial |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Open‐ label trial |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Attrition rates reported, ITT approach, all randomised participants analysed from IPD provided (see footnote 2) |
Selective reporting (reporting bias) | Low risk | All outcomes reported or calculated with IPD provided (see footnote 2) |
Other bias | Low risk | None identified |