Eun 2012

Methods	Randomised, multicentre, open‐label, parallel‐group trial conducted in 7 hospitals in Republic of Korea 2 treatment arms: LTG and CBZ
Participants	Children aged 6‐12 years with a new diagnosis of partial epilepsy and at least 2 seizures in the last 6 months. Number randomised: LTG = 43, CBZ = 41 48 male participants (57%) 100% of participants had partial epilepsy Not stated if any participants had received previous AED treatment Mean age (range): 9 (5‐13) years
Interventions	Monotherapy with LTG or CBZ 8‐week escalation phase leading to LTG = 3‐6 mg/kg/d, CBZ = 10‐20 mg/kg/d Range of follow‐up: 0.5‐28 months
Outcomes	Seizure‐free rate over 6 months (maintenance period) by treatment group Change in cognition (neuropsychological), behaviour and quality of life from screening to the end of the maintenance phase by treatment group Incidence of adverse events
Notes	IPD provided by trial author for time to treatment withdrawal, time to first seizure and time to 6‐month remission
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Each centre received a separate and independent computer‐ generated random code list
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label trial
Blinding of outcome assessment (detection bias) All outcomes	High risk	Open‐label trial
Incomplete outcome data (attrition bias) All outcomes	Low risk	Attrition rates reported, all randomised participants analysed from IPD provided (see footnote 2)
Selective reporting (reporting bias)	Low risk	All outcomes reported or calculated with IPD provided (see footnote 2)
Other bias	Low risk	None identified