Lee 2011

Methods	Randomised, multicentre, open‐label, parallel‐group trial conducted in the Korea 2 treatment arms: LTG and CBZ
Participants	Adults over the age of 16 with newly diagnosed partial epilepsy or untreated partial epilepsy for at least one year Number randomised: LTG = 57, CBZ = 53 57 male participants (52%) 95 participants with partial epilepsy (86%) Not stated how many participants had received previous AED treatment Mean age (range): 36 (16‐60) years
Interventions	Monotherapy with LTG or CBZ 8‐week escalation phase leading to LTG = 200 mg/d, CBZ = 600 mg/d Range of follow‐up: 0‐16.5 months
Outcomes	Change of neuropsychological and cognitive scores from baseline: general intellectual ability, learning and memory, attention and executive function (group‐by‐time interaction) Frequency of psychological and health‐related quality of life symptoms Proportion with seizure freedom during the maintenance period
Notes	IPD provided by trial author for time to treatment withdrawal, time to first seizure and time to six‐month remission
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Block randomisation (block size four) via a computer randomisation programme (information provided by trial author)
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label trial
Blinding of outcome assessment (detection bias) All outcomes	High risk	Open‐label trial
Incomplete outcome data (attrition bias) All outcomes	Low risk	Attrition rates reported, all randomised participants analysed from IPD provided (see footnote 2)
Selective reporting (reporting bias)	Low risk	All outcomes reported or calculated with IPD provided (see footnote 2)
Other bias	Low risk	None identified