Lukic 2005

Methods	Prospective, open‐label randomised trial conducted in Serbia and Montenegro 2 treatment arms: LTG and VPS
Participants	Participants with newly diagnosed, previously untreated epilepsy Number randomised: LTG = 35, VPS = 38 51 (70%) with partial epilepsy Median age (range): 34 (18‐76) years No information on gender
Interventions	Monotherapy with LTG or VPS All participants to be followed up for at least 6 months
Outcomes	Seizure freedom Retention on treatment
Notes	Abstract of interim results only available. Contact was made with trial author who was unable to provide IPD
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Trial described as randomised, no further information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label trial
Blinding of outcome assessment (detection bias) All outcomes	High risk	Open‐label trial
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Interim report, proportion of participants completing the trial period presented. Unclear if an ITT approach was taken to analysis
Selective reporting (reporting bias)	Unclear risk	Abstract only, insufficient information to make a judgement
Other bias	Low risk	None identified