1 Global state: No clinically important overall improvement (as rated by trialists) |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
1.1 short term |
1 |
61 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.82 [0.55, 1.24] |
1.2 medium term |
2 |
133 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.38 [0.24, 0.59] |
2 Mental state: General ‐ 1a. Average endpoint score (PANSS, high score = poor) |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
2.1 short term |
1 |
75 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.69 [‐1.16, ‐0.23] |
2.2 medium term |
2 |
159 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.97 [‐1.31, ‐0.63] |
2.3 long term |
1 |
90 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐3.41 [‐4.07, ‐2.76] |
3 Mental state: General ‐ 1b. Average endpoint score (BPRS, high score = poor) |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
3.1 short term |
1 |
30 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.27 [‐0.45, 0.99] |
3.2 medium term |
1 |
70 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐1.25 [‐1.77, ‐0.73] |
4 Mental state: Specific ‐ 2. Negative symptoms ‐ average endpoint score (SANS, high score = poor) |
7 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
4.1 short term |
5 |
319 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.50 [‐0.73, ‐0.27] |
4.2 medium term |
3 |
177 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.55 [‐0.87, ‐0.24] |
5 Mental state: Specific ‐ 3. Positive symptoms ‐ average endpoint score (SAPS, high score = poor) |
1 |
96 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.18 [‐0.60, 0.24] |
5.1 short‐term |
1 |
96 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.18 [‐0.60, 0.24] |
6 Mental state: Specific ‐ 4a. Depression ‐ average endpoint score (SDS, high score = poor) |
2 |
90 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.63 [‐1.06, ‐0.21] |
6.1 short term |
2 |
90 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.63 [‐1.06, ‐0.21] |
7 Mental state: Specific ‐ 4b. Depression ‐ average endpoint score (Ham‐D, high score = poor) |
1 |
30 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.52 [‐1.25, 0.21] |
7.1 short term |
1 |
30 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.52 [‐1.25, 0.21] |
8 Mental state: Specific ‐ 4c. Depression ‐ average endpoint score (CDSS, high score = poor)) |
1 |
75 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.73 [‐1.20, ‐0.26] |
8.1 short term |
1 |
75 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.73 [‐1.20, ‐0.26] |
9 Mental state: Specific ‐ 5. Anxiety ‐ average endpoint score (SAS, high score = poor) |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.61 [‐1.13, ‐0.09] |
9.1 short term |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.61 [‐1.13, ‐0.09] |
10 Leaving the study early |
18 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
10.1 short term |
11 |
692 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.14 [0.02, 1.06] |
10.2 medium term |
8 |
531 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.62 [0.30, 1.30] |
10.3 long term |
2 |
151 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.97 [0.50, 1.89] |
11 Functioning: General ‐ 1a. Average endpoint score (GAF, high score = good) |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
11.1 short term |
1 |
53 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.08 [‐0.47, 0.62] |
11.2 medium term |
2 |
118 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.19 [‐0.56, 0.18] |
12 Functioning: General ‐1b. Average endpoint score (IADL, high score = poor) |
1 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
12.1 medium term |
1 |
90 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐1.20 [‐1.65, ‐0.75] |
12.2 long term |
1 |
90 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐1.80 [‐2.29, ‐1.30] |
13 Functioning: Social 2a. Average endpoint score (SDSS, high score = poor) |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
13.1 short term |
1 |
40 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐1.25 [‐1.94, ‐0.57] |
13.2 medium term |
2 |
160 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.72 [‐1.04, ‐0.40] |
13.3 long term |
1 |
90 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.56 [‐0.98, ‐0.14] |
14 Functioning: Cognitive ‐ 3a. Attention ‐ average endpoint score (PASAT, high score = good) |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.72 [0.22, 1.21] |
14.1 medium term |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.72 [0.22, 1.21] |
15 Functioning: Cognitive ‐ 3b. Vigilance and attention ‐ average endpoint score (CCPT, high score = good) |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.25 [‐0.23, 0.74] |
15.1 medium term |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.25 [‐0.23, 0.74] |
16 Functioning: Cognitive ‐ 3c. Memory ‐ average endpoint score (WMS, high score = good) |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.43 [‐0.06, 0.92] |
16.1 medium term |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.43 [‐0.06, 0.92] |
17 Functioning: Cognitive ‐ 3d. Memory ‐ average endpoint score (CMT, high score = good) |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.58 [0.06, 1.09] |
17.1 short term |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.58 [0.06, 1.09] |
18 Functioning: Cognitve ‐ 3e. Abstract thinking ‐ average endpoint score (BCST, high score = good) |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.09 [‐0.39, 0.58] |
18.1 medium‐term |
1 |
67 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.09 [‐0.39, 0.58] |
19 Functioning: Cognitive ‐ 3f. Abstract thinking ‐ average endpoint score (WCST‐Cc, high score = good) |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
19.1 short term |
2 |
90 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.02 [‐0.07, 0.03] |
19.2 medium term |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
1.18 [0.33, 2.03] |
20 Behaviour: 1. Average endpoint general behaviour score (NOSIE, high score = good) |
2 |
100 |
Std. Mean Difference (IV, Fixed, 95% CI) |
1.38 [0.93, 1.84] |
20.1 short term |
2 |
100 |
Std. Mean Difference (IV, Fixed, 95% CI) |
1.38 [0.93, 1.84] |
21 Behaviour: 2. Average change in general behaviour score (NOSIE, high score = good)) |
1 |
62 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.69 [0.18, 1.20] |
21.1 medium term |
1 |
62 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.69 [0.18, 1.20] |
22 Recipient of care satisfaction: Average endpoint score (CSQ, high score = good) |
1 |
69 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.32 [‐0.16, 0.80] |
22.1 medium term |
1 |
69 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.32 [‐0.16, 0.80] |
23 Quality of life: General ‐ average endpoint score (GWB, high score = good) |
1 |
72 |
Std. Mean Difference (IV, Fixed, 95% CI) |
1.82 [1.27, 2.38] |
23.1 short term |
1 |
72 |
Std. Mean Difference (IV, Fixed, 95% CI) |
1.82 [1.27, 2.38] |
24 Quality of life: Specific 1. Mental health ‐ average endpoint score (SPG, high score = good) |
1 |
31 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.05 [‐0.66, 0.75] |
24.1 short term |
1 |
31 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.05 [‐0.66, 0.75] |
25 Quality of life: Specific 2. Perceived social support ‐ average endpoint score (SSQ, high score = good) |
1 |
72 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.73 [0.26, 1.21] |
25.1 short term |
1 |
72 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.73 [0.26, 1.21] |