Cooper 1985.
| Methods | RCT. Parallel design. Duration: unspecified. Single centre. Country: Canada. |
|
| Participants | 18 participants with CF and an exacerbation and P. aeruginosa infection. Intervention 1: 10 participants. Intervention 2: 8 participants. |
|
| Interventions | Intervention 1: IV tobramycin and IV ticarcillin (dose and regimen unstated). Intervention 2: inhaled tobramycin and inhaled carbenicillin (dose and regimen unstated). |
|
| Outcomes | Lung function (FEV1, FVC % predicted). | |
| Notes | We shall seek to contact the authors for IPD to include in any meta‐analysis. Currently SDs for the mean changes observed are not available. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Described as randomly allocated but no detail given. |
| Allocation concealment (selection bias) | Unclear risk | No detail given. |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | No detail given. |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No detail given. |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | 2 participants in each group needed additional antibiotics. Unclear if this was analysed as ITT. |
| Selective reporting (reporting bias) | Unclear risk | Insufficient evidence. |
| Other bias | Low risk | None identified. |