Costantini 1982.

Methods	RCT. Parallel design. Duration: mean duration of 15 days. Single centre. Country: Italy.
Participants	19 participants with CF colonised with P. aeruginosa experiencing an exacerbation over 28 exacerbation episodes. Intervention 1: 7 participants. Intervention 2: 10 participants. Invtervention 3: 11 participants.
Interventions	Intervention 1: IV carbenicillin 675 mg/kg/day (mean dosage). Intervention 2: IV sisomicin 10.5 mg/kg/day (mean dosage). Invtervention 3: IV carbenicillin 590 mg/kg/day AND IV sisomicin 10 mg/kg/day (mean dosage).
Outcomes	Unvalidated clinical score, microbiology and adverse effects.
Notes	We shall seek to contact the authors for IPD to reconcile the UoA issues and quantify unpublished data.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised but no detail given.
Allocation concealment (selection bias)	Unclear risk	No detail given.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No detail given.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No detail given.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No withdrawals described.
Selective reporting (reporting bias)	Unclear risk	Insufficient information.
Other bias	High risk	UoA issues ‐ 19 participants contributed 28 treatment episodes.