Latzin 2008.
Methods | Open‐label RCT for 3 indications: (1) suppression therapy for those with chronic P. aeruginosa not experiencing an exacerbation; (2) acute exacerbation in those with chronic P. aeruginosa infection; and (3) eradication of first detection of P. aeruginosa infection. |
Participants | 127 participants enrolled, of whom 34 were recruited as they had chronic P. aeruginosa infection and were experiencing an acute exacerbation. |
Interventions | Intervention 1: IV meropenem 120 mg/kg/day in 3 doses and IV tobramycin 9 ‐ 12 mg/kg/day in 2 doses. Intervention 2: IV ceftazidime 200 ‐ 400 mg/kg/day in 2 or 3 doses and tobramycin 9 ‐ 12 mg/kg/day in 2 doses. |
Outcomes | Lung function, adverse effects, microbiology. |
Notes | While a subgroup analysis consisting of the 3 indications is described for lung function, data are presented as a whole. Participants could be recruited 2x although this is not described. We shall seek to contact the authors for IPD to reconcile the UoA issues and for data to contribute to a meta‐analysis. |