Skip to main content
. 2015 Jul 30;2015(7):CD009730. doi: 10.1002/14651858.CD009730.pub2

Latzin 2008.

Methods Open‐label RCT for 3 indications:
(1) suppression therapy for those with chronic P. aeruginosa not experiencing an exacerbation;
(2) acute exacerbation in those with chronic P. aeruginosa infection; and
(3) eradication of first detection of P. aeruginosa infection.
Participants 127 participants enrolled, of whom 34 were recruited as they had chronic P. aeruginosa infection and were experiencing an acute exacerbation.
Interventions Intervention 1: IV meropenem 120 mg/kg/day in 3 doses and IV tobramycin 9 ‐ 12 mg/kg/day in 2 doses.
Intervention 2: IV ceftazidime 200 ‐ 400 mg/kg/day in 2 or 3 doses and tobramycin 9 ‐ 12 mg/kg/day in 2 doses.
Outcomes Lung function, adverse effects, microbiology.
Notes While a subgroup analysis consisting of the 3 indications is described for lung function, data are presented as a whole.
Participants could be recruited 2x although this is not described.
We shall seek to contact the authors for IPD to reconcile the UoA issues and for data to contribute to a meta‐analysis.