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. 2017 Jun 28;2017(6):CD012217. doi: 10.1002/14651858.CD012217.pub2

Shao 2014.

Methods Allocation: randomised.
Blindness: not stated.
Duration: 6 weeks.
Participants Diagnosis: schizophrenia (CCMD‐3; TCM Diagnostic criteria cited from text book of “TCM Internal Medicine”).
N = 200.
Age: 17‐62 years.
Sex: 107 men 93 women.
History: average duration ill ˜ 4 years (SD ˜ 0.8).
Inclusion criteria: Aged 17‐62; Patients and their families signed the informed consent.
Exclusion criteria: Other diseases or complications; accepted related treatments, and may affect observations; accompanied with situations that may affect observations; serious heart, liver and kidney damage, affect drug metabolism; special groups (pregnant women, lactating women, infants, minors, the elderly, critical condition, terminally ill); patients who were receiving drug treatment, could be included after a washout period.
Interventions 1. WDD (please see details in Table 5) + antipsychotics (Exciting: quetiapine 300 mg to 600 mg twice daily and olanzapine 10 mg to 30 mg twice daily; looks dull, visual hallucinations, auditory hallucinations: perphenazine 20 mg to 40 mg twice daily, risperidone 3 mg to 6 mg twice daily, clozapine 200 mg to 400 mg twice daily.). N = 100.
 2. Antipsychotics (Exciting: quetiapine 300 mg to 600 mg twice daily and olanzapine 10 mg to 30 mg twice daily; looks dull, visual hallucinations, auditory hallucinations: perphenazine 20 mg to 40 mg twice daily, risperidone 3 mg to 6 mg twice daily, clozapine 200 mg to 400 mg twice daily). N = 100.
Outcomes Global state: cure (binary 'symptoms disappeared' ‐ all, partly, slightly , no change).
Mental state: BPRS total scores.
Mental state: PANSS negative subscale score, positive subscale score, and PANSS total score.
Adverse effects: RSESE, constipation (dry stool), abnormal liver function.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "randomly divided in to intervention group and control according to random number table…"
Allocation concealment (selection bias) Unclear risk Not stated.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not stated.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not stated.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No missing outcome data.
Selective reporting (reporting bias) Low risk We were unable to locate original study protocol, however, all outcomes listed in the 'methods' section of the paper appear to have been measured and reported.
Other bias Low risk No obvious other bias.