Sun 2014.
Methods | Allocation: randomised. Blindness: not stated. Duration: 2 months. |
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Participants | Diagnosis: schizophrenia (CCMD‐3; PANSS > = 60). N = 108. Age: 18‐71 years. Sex: 51 men 43 women. History: average duration ill ˜ 6 years (SD ˜ 3). Inclusion criteria: not stated. Exclusion criteria: not stated. |
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Interventions | 1. WDD (please see details in Table 5) + aripiprazole (dose stared from 5 mg/d, and increased individually, but did not exceed 30 mg/d.). N = 54. 2. Aripiprazole (dose stared from 5 mg/d, and increased individually, but did not exceed 30 mg/d). N = 54. | |
Outcomes | Global state: cure (binary PANSS scores ‐ reduced >75%, 50% to 74%, 25% to 49%, no effect ‐ <24%). Mental state: PANSS total. Adverse events: EPS, weight gain, constipation (dry stool) (TESS). |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "randomly divided in to intervention group and control …" |
Allocation concealment (selection bias) | Unclear risk | Not stated. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Not stated. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not stated. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing outcome data. |
Selective reporting (reporting bias) | Low risk | We were unable to locate original study protocol, however, all outcomes listed in the 'methods' section of the paper appear to have been measured and reported. |
Other bias | Low risk | No obvious other bias. |