Table 8. Verification of B entities from the context-assignment-based ABC model (APOE-MAPT).
| B entity | Verifi- cation |
Evidence | |
|---|---|---|---|
| 1 | app | O | 1) ApoE elevates the transcription of APP. 2) APP metabolism regulates mapt proteostasis[47]. |
| 2 | bace1 | O | 1) APOE and bace1 levels show relation 2) Mapt hyperphosphorylation is related with increased bace1 |
| 3 | bche | O | 1) ApoE and bche functions as modulators of cerebral amyloid deposition [40]. 2) BChE-K(BChE varient) is associated with reduced mapt phosphorylation [41]. |
| 4 | c9orf72 | O | 1) c9orf72 is a stronger determinant than Apoe of cognitive impairment in ALS [42]. 2) Mutations in c9orf72 and mapt are found in familial frontotemporal dementia [43]. |
| 5 | clu | X | ApoE, clu, and mapt have no direct relation. |
| 6 | cr1 | O | CR1 interacts with APOE and affects mapt. |
| 7 | ctsd | O | 1) CTSD and APOE have been associated with cognitive ability 2) CTSD is associated with degrading mapt |
| 8 | cyp46a1 | O | CYP46A1 may interact with APOE to influence phospho-mapt protein |
| 9 | gfap | O | GFAP-apoE is associated with increased phosphorylation of mapt |
| 10 | grn | X | APOE and grn are in independent pathway having no relation |
| 11 | hfe | O | 1) HFE mutations correlate with APOE 2) HFE increases mapt phosphorylation |
| 12 | ins | O | 1) ApoE4 reduces brain insulin (ins) [38] 2) Insulin dysfunction induces in vivo mapt hyperphosphorylation [39]. |
| 13 | mcidas | X | 1) ApoE is required for cell cycle regulation (mcidas plays a role in mitotic cell cycle progression by promoting cell cycle exit) [45]. 2) No direct evidence of interaction between mcidas and mapt. |
| 14 | phgdh | O | 1) ApoE and phgdh have interaction [36] 2) Serine (phgdh is involved in serine synthesis) mutations in mapt increases mapt aggregation [37] |
| 15 | picalm | O | 1) PICALM and APOE is associated 2) PICALM modulates mapt accumulation [48]. |
| 16 | prnp | X | Pnrp and fus are in independent path ways not affecting each other |
| 17 | rcan1 | O | ApoE genotype shows higher levels of RCAN1 and phospho-ta |
| 18 | sars2 | X | APOE and sars2 are in independent pathway having no relation |
| 19 | snca | X | 1) SNCA as well as ApoE has been associated with cognitive decline in neurodegenerative disease [35]. 2) SNCA, mapt have no direct relation. |
| 20 | tardbp | O | 1) APOE formed complex with TARDBP 2) TARDBP and mapt protein levels are related |