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. 2019 Apr 12;17(4):e2006506. doi: 10.1371/journal.pbio.2006506

Fig 5. Inducible expression of Myc defines Myc-responsive and Myc-unresponesive Ikaros target genes.

Fig 5

(A) Expression of Ikaros-ERt2 and Myc-ERt2 in B3 cells as detected by western blotting. (B) Chromatin RNA-seq showed that the expression of 2,809 genes was regulated by Myc (adj. P < 0.05) and the expression of 1,978 genes was regulated by Ikaros (adj. P < 0.05) in B3 cells. Of these, 587 genes were responsive to Myc and also to Ikaros (top). GO analysis of the biological function of Myc- and Ikaros-regulated genes, and of Ikaros-regulated genes that are also regulated by Myc (Myc-responsive) or not regulated by Myc (not Myc responsive, bottom). The top GO terms are shown; numbers and P values are indicated. The source of the numerical data underlying this figure is listed in S1 Data. ERt2, mutant estrogen receptor; GO, gene ontology; HA, haemagglutinin; Myc, MYC proto-oncogene; RNA-seq, RNA sequencing.