Supplementary Table 1.

eGFR decline ≥ 40 mL/min/1.73 m² from baseline outcomes among groups classified by Framingham risk score with multivariate Cox regression analysis

	Total	Framingham risk score groups
		Low risk	Intermediate risk	High risk
≥ 40 eGFR decline
Events	679	450	133	96
Events/1,000 person-year	9.9	8.6	7.7	9.9
Model 1	HR (95% CI)	1 [reference]	0.917 (0.756–1.113)	1.280 (1.026–1.595)
	P		0.379	0.028
Model 2	HR (95% CI)	1 [reference]	0.958 (0.786–1.168)	1.313 (1.044–1.651)
	P		0.674	0.020
Model 3	HR (95% CI)	1 [reference]	1.356 (1.106–1.662)	2.182 (1.717–2.772)
	P		0.003	< 0.001
Model 4	HR (95% CI)	1 [reference]	1.222 (0.989–1.509)	1.727 (1.341–2.224)
	P		0.063	< 0.001

Data are presented as number person-year or incidence rate per 1,000 person-year.

Model 1, crude hazard ratio (HR) without adjustment; Model 2, adjusted for residence (Ansan or Anseong), education status, income, history of coronary artery disease, alcohol intake (non-drinker, ex-drinker, or current drinker); Model 3, model 2 + eGFR and proteinuria; Model 4, model 3 + fasting glucose, albumin, triglyceride, C-reactive protein, and calculated low density lipoprotein.

CI, confidence interval; eGFR, estimated glomerular filtration rate.