Table 3.

Thyroid Status in Patients With Extreme Insulin Resistance at the Time of Thyroid Imaging

Parameter/Disease	All Patients			Patients <19 y of Age
	INSR Mutation Group	Lipodystrophy Group	P Value	INSR Mutation Group	Lipodystrophy Group	P Value
TSH, μIU/mL (range); n	1.78 ± 1.38	1.89 ± 1.2	0.5	2 ± 1.7	2.3 ± 1.6	0.6
	(0.42–5.1); n = 11	(0.37–6.1); n = 74		(0.42–5.1); n = 7	(0.58–6.08); n = 20
fT4, ng/dL (range); n	1.43 ± 0.46	1.22 ± 0.2	0.2	1.4 ± 0.6	1.27 ± 0.17	0.5
	(0.8–1.9); n = 4	(0.9–1.8); n = 50		(0.8–1.9); n = 3	(1.1–1.6); n = 14
TT4, μg/dL (range); n	8.73 ± 1.7	7.34 ± 2.2	0.1	9.2 ± 2.3	7.46 ± 1.4	0.4
	(7–11.7); n = 7	(4.7–15); n = 22		(7.3–11.7); n = 3	(5.3–9.2); n = 5
TT3, ng/dL (range); n	114 ± 33	120 ± 32.4	0.7	133.8 ± 35.4	142.2 ± 42	0.9
	(71–158.8); n = 6	(75.7–219); n = 25		(108.8–158.8); n = 2	(86.2–219); n = 7
Anti-Thyroglobulin antibodies,a %	n = 11	n = 80	0.7	n = 7	n = 23	0.9
Negative	73	80		57.4	61
Detectable	9	6		14.3	13
Unknown	18	14		28.6	26
Anti–thyroid peroxidase antibodies,a %	n = 11	n = 80	0.9	n = 7	n = 23	0.7
Negative	64	61		43	52
Detectable	18	25		29	22
Unknown	18	14		29	26

^aAntithyroid antibodies were checked at any time point, including in patients on replacement therapy.