. 2019 Jan 16;104(6):2216–2228. doi: 10.1210/jc.2018-02289

Table 4.

Blood Glucose Parameters and IGF-1/IGF-2 Levels in Lipodystrophy and INSR Mutation Patients at the Time of Thyroid US

	INSR ^−/−	INSR ^+/−	Lipodystrophy	P Value (ANOVA)
Fasting insulin, μU/mL	626 ± 390	136 ± 124	64 ± 121	0.0005^a
Fasting blood glucose, mg/dL	135 ± 75	97 ± 14	125 ± 54	0.5^a^,^b^,^c
AUC during OGTT for insulin, μU/mL/190 min	1,103,313 ± 18,496	72,758 ± 48,780	28,596 ± 31,238	0.0005 ^a ^, ^c
AUC during OGTT for blood glucose, mg/dL/190 min	50,966 ± 16,478	34,865 ± 13,239	39,873 ± 16,930	0.3^a^,^b^,^c
HbA1c, %	11.2 ± 1.8	6.3 ± 1.7	7.1 ± 2.1	0.003 ^a ^, ^b
IGF-1, ng/mL	33 ± 19	366 ± 218	183 ± 96	<0.0001^a^,^b^,^c
IGF-2, ng/m)	136 ± 123	347 ± 69	449 ± 125	0.0026 ^a

P < 0.05 by post hoc Dunn multiple comparison. Boldface indicates statistically significant P value (P < 0.05).

^{^a}

Homozygous INSR mutation vs lipodystrophy group.

^{^b}

Homozygous vs heterozygous INSR mutation.

^{^c}

Heterozygous INSR mutation vs lipodystrophy group.