Table 5.
Thyroid Volume in Patients With Extreme Insulin Resistance at the Time of Thyroid Imaging
| All Patients |
Patients <19 y of Age |
|||||
|---|---|---|---|---|---|---|
| INSR Mutation Group (n = 11) | Lipodystrophy Group (n = 70) | P Value | INSR Mutation Group (n = 7) | Lipodystrophy Group (n = 21) | P Value | |
| Right lobe, mL (range) | 5.1 ± 3.5 (1.3–13) | 5.8 ± 3.4 (1–20.1) | 0.3 | 3.9 ± 2.3 (1.3–7.8) | 4.4 ± 0.8 (1–20.1) | 0.9 |
| Left lobe, mL (range) | 4.3 ± 3.6 (0.9–13.7) | 4.6 ± 3.3 (0.4–21.15) | 0.5 | 2.9 ± 1.5 (0.9–5.1) | 3.8 ± 4.4 (0.4–21) | 0.9 |
| Total volume, mL (range) | 9.3 ± 7.1 (2.3–26.6) | 10.4 ± 6.3 (1.5–41.2) | 0.3 | 6.9 ± 3.7 (2.3–13) | 8.2 ± 8.4 (1.5–41.2) | 0.9 |
| Total volume per BSA, mL/m2 (range) | 6.8 ± 4.8 (1.8–16.6) | 6.2 ± 3.4 (1.3–22); (n = 64) | 0.9 | 5.7 ± 3.8 (1.8–13.6) | 5.4 ± 4.3 (1.3–22) | 0.7 |
| Not enlarged/enlarged thyroid volume based on age, %a | 91/9 | 83/17 | 0.7 | 100/0 | 81/19 | 0.3 |
| Not enlarged/enlarged thyroid volume based on BSA, %b | 70/30 (n = 10) | 88/12 (n = 51) | 0.07 | 86/14 | 95/5 (n = 20) | 0.3 |
Patients were excluded from the analysis when they had history of thyroid surgery, were taking thyroid hormone, or in whom thyroid volume could not be assessed due to limited US images.
a
Thyroid volumes in subjects <20 y of age were compared with reference ranges for age (25). Thyroid volume in adults (20 to 70 y of age) were compared with adult reference ranges (26).
2
Thyroid volumes in both pediatric and adult subjects were compared with reference ranges for BSA derived from children <20 of age (25).