Table 1.
Characteristics of Normal-Weight Control Subjects vs Women With PCOS
| Control (n = 18) | PCOS (n = 10) | P Value | |
|---|---|---|---|
| Age, y | 27.2 ± 1.2 | 26.0 ± 1.6 | 0.560 |
| BMI, kg/m2 | 21.6 ± 0.4 | 22.4 ± 0.6 | 0.273 |
| Waist, cm | 75.7 ± 1.0 | 76.2 ± 1.7 | 0.782 |
| Hip, cm | 89.4 ± 1.3 | 88.0 ± 1.8 | 0.541 |
| Log LH, mIU/mL | 0.87 ± 0.05 | 1.11 ± 0.08 | 0.016a |
| Total testosterone, ng/dL | 29.5 ± 2.0 | 63.4 ± 5.2 | <0.001a |
| Free testosterone, pg/mL | 2.3 ± 0.3 | 6.0 ± 0.5 | <0.001a |
| A4, ng/dL | 111.3 ± 8.4 | 201.4 ± 27.5 | 0.010a |
| DHT, ng/dL | 9.8 ± 0.6 | 12.7 ± 2.1 | 0.217 |
| DHEAS, μg/dL | 190.8 ± 23.0 | 224.0 ± 20.1 | 0.341 |
| Adipose-IR, pmol/L × mmol/L | 18.3 ± 1.6 | 31.9 ± 3.8 | 0.007a |
| Fasting insulin, μU/mL | 4.7 ± 0.5 | 6.1 ± 0.7 | 0.094 |
| Total FFAs, mmol/L | 0.59 ± 0.06 | 0.74 ± 0.07 | 0.111 |
| HOMA-IR | 1.0 ± 0.1 | 1.3 ± 0.2 | 0.143 |
| Lipid accumulation product | 10.7 ± 1.2 | 20.4 ± 7.7 | 0.242 |
| Visceral adiposity index | 0.7 ± 0.1 | 1.5 ± 0.7 | 0.242 |
| Triglyceride index | 3.3 ± 0.1 | 3.5 ± 0.1 | 0.095 |
| Log of triglycerides, mg/dL | 1.71 ± 0.03 | 1.87 ± 0.08 | 0.088 |
| Total cholesterol, mg/dL | 156.2 ± 7.2 | 153.4 ± 10.8 | 0.828 |
| HDL-cholesterol, mg/dL | 65.4 ± 2.8 | 60.3 ± 4.4 | 0.308 |
| LDL-cholesterol, mg/dL | 79.2 ± 5.9 | 74.7 ± 9.3 | 0.671 |
| Non–HDL-cholesterol, mg/dL | 89.7 ± 6.3 | 93.0 ± 10.0 | 0.774 |
| SHBG, nmol/L | 68.2 ± 8.1 | 49.1 ± 5.6 | 0.064 |
| Fasting glucose, mg/dL | 85.0 ± 1.5 | 85.4 ± 1.4 | 0.866 |
| HMW adiponectin, ng/mL | 3330 ± 407 | 3084 ± 778 | 0.759 |
| Leptin, ng/mL | 25.2 ± 3.2 | 24.5 ± 3.2 | 0.882 |
| Si (×10−4/min/μU/mL | 6.2 ± 1.2 | 4.8 ± 0.8 | 0.351 |
| Log AIRg, μU/mL | 2.43 ± 0.04 | 2.56 ± 0.06 | 0.071 |
| DI [(Si × AIRg/100] | 20.4 ± 3.6 | 17.4 ± 2.6 | 0.516 |
| Sg (×10/min | 0.02 ± 0.00 | 0.02 ± 0.01 | 0.504 |
| (n = 16) | (n = 9) | ||
| Total body mass, kg | 61.9 ± 1.9 | 61.7 ± 2.8 | 0.945 |
| Lean body mass, kg | 39.8 ± 1.2 | 40.4 ± 1.8 | 0.790 |
| Total body fat mass, kg | 19.7 ± 0.8 | 19.8 ± 1.3 | 0.984 |
| Percent body fat | 31.8 ± 0.7 | 32.0 ± 1.4 | 0.898 |
| Percent android fat | 5.6 ± 0.2 | 6.6 ± 0.4 | 0.063 |
| Percent gynoid fat | 21.5 ± 0.4 | 20.7 ± 0.3 | 0.152 |
| (n = 15) | (n = 8) | ||
| Small adipocytes, mean ± SEM, % | 10.7 ± 1.3 | 18.2 ± 2.4 | 0.006a |
Conversions to SI units: LH, ×1.0 IU/L; testosterone, ×0.0347 nmol/L; free testosterone, ×3.47 pmol/L; A4, ×0.0349 nmol/L; DHT, ×0.0344 nmol/L; DHEAS, ×0.0271 μmol/L; insulin, ×7.175 pmol/L; TG, ×0.0113 mmol/L; total cholesterol, HDL-cholesterol, LDL-cholesterol, non–HDL-cholesterol, ×0.0259 mmol/L; glucose, ×0.0555 mmol/L; HMW adiponectin, ×0.001 μg/L; leptin, ×1.0 μg/L.
a
Statistically significant at P < 0.05.