Scheme 1.

Comparison of previous electrochemical methods for sp³ C–H amination. For detail procedures, see refs. 12–14 and Supporting Information. Yields were determined by ¹H NMR with m-xylene as internal standard, conversion is shown in parenthesis. [a] Conditions: 1a or 1b (0.2 mmol) and ⁿBu₄NPF₆ (0.1 M) in HFIP (10 mL), 2.5 mA, RT. [b] Conditions: 1a or 1b (0.2 mmol), NaOAc (0.2 mmol) and ⁿBu₄NBF₄ (0.2 mmol) in DCE/HFIP (6 mL, 2:1), 7.5 mA, RT. [c] 1a or 1b (0.4 mmol), NaOMe (0.2 mmol) and KBr (0.2 mmol) in methanol (6 mL) at 65 °C, 100 mA, DCE = 1,2-dichloroethane. HFIP = 1,1,1,3,3,3-hexafluoro-2-propanol. n.d. = not detected.