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Spheroids found in human, rat and pig NCC. Amyloid precursor protein (APP) staining shows that spheroids are present in human and rat NCC. Cases 1–3 demonstrate axonal swellings while in case 4 axonal swellings are less conspicuous among inflammatory changes. Pig samples do not show evidence of spheroids positive for APP (not shown) but axonal swellings were detected with high/medium‐MW neurofilament (HM NfP) IHC.
