Table 1.
NCC neuroinflammatory characteristics
| Sham | Parenchyma | P‐value* | Meninges | P‐value† | Ventricle | ||||
|---|---|---|---|---|---|---|---|---|---|
| Intracranial route | Oral route | Intracranial route | Oral route | Intracranial route | |||||
| Cyst dimensions and area | Cysticercus Diameter | – | 2705 ± 177 | 2003 ± 223 | 0.08 | 2350 ± 196 | 1921 ± 609 | 0.39 | 2036 ± 206 |
| Cyst area as % of brain area | – | 10.50 ± 1.4 | 7.65 ± 0.97 | 0.33 | 8.08 ± 1.04 | 7.25 ± 0.86 | 0.72 | 6.52 ± 1.60 | |
| Histopathological changes | Spongy changes | 0 | 34.09 ± 5.99 | 18.33 ± 7.26 | 0.10 | 18.75 ± 5.05 | 6.25 ± 1.25 | 0.50 | 11.00 ± 9.80 |
| Perivascular cuffing | 0 | 9.55 ± 0.81 | 5.00 ± 0.00 | 0.01 | 5.94 ± 0.94 | 5.00 ± 0.00 | 0.50 | 5.00 ± 1.58 | |
| Frequency of cells with nuclear pyknosis | 0 | 91% | 100% | 0.60 | 100% | 100% | nd | 80% | |
| Thickness of collagen layer | 0 | 28.14 ± 3.89 | 26.02 ± 9.68 | 0.80 | 30.33 ± 5.31 | 28.14 ± 8.52 | 0.80 | 12.41 ± 7.26 | |
| Inflammatory cell infiltrate | Macrophages | 0 | 19.45 ± 3.48 | 22.00 ± 11.02 | 0.50 | 13.88 ± 1.58 | 18.00 ± 8.67 | 0.20 | 31.20 ± 10.42 |
| Heterophils | 0 | 12.55 ± 2.08 | 6.67 ± 0.88 | 0.03 | 9.75 ± 0.87 | 6.50 ± 0.50 | 0.02 | 15.60 ± 4.88 | |
| Plasmocytes | 0 | 60.45 ± 6.33 | 33.67 ± 1.76 | 0.01 | 50.88 ± 3.97 | 31.25 ± 0.48 | 0.02 | 58.80 ± 13.60 | |
| Lymphocytes | 0 | 38.27 ± 6.45 | 21.33 ± 3.76 | 0.18 | 26.81 ± 2.47 | 20.50 ± 1.89 | 0.39 | 39.40 ± 10.23 | |
NCC neuroinflammatory characteristics. Dimensions and Cyst area, histopathological alterations and inflammatory cell infiltrate were analyzed in the tissue surrounding the cysticercus by H&E staining and are presented as mean ± SEM. Sham groups from either intracranial and oral routes of infection did not show any degree of inflammatory cell infiltrate in the brain tissue. Cysticercus diameter (µm) is the mean of two measurements. % cystcicercus area is the percentage area occupied by the cyst as a proportion of the total brain area per H&E stained section. Spongy changes were characterized by fluid‐filled spaces of variable size in the tissue surrounding the cysticercus. Perivascular cuffing refers to a variable cell infiltrate around small brain vessels in the tissue surrounding the cysticercus. Pyknotic cells were characterized by nuclear shrinking. The thickness of the collagen layer was obtained by the mean of 4–6 measurements of the collagen layer surrounding the cysticerci. Heterophils refer to either eosinophils or neutrophils.
P‐value represents individual P‐values of the two‐sample test of ranges (Mann‐Whitney) between each variable for parenchymal cysticerci by intracranial vs. oral route.
P‐value represents individual P‐values of the two‐sample test of ranges (Mann‐Whitney) between each variable for meningeal cysticerci by intracranial vs. oral route.