Fig. 1.

Sequence analyses of recovered anti-α-synuclein antibodies. a Number of somatic mutations in V_H and V_L genes of 10 antibodies recovered from IgG⁺ memory B cells with reactivity to α-synuclein. The closest germline and mutations were determined using IgBlast and IMGT databases. The horizontal lines indicate medians b Phylogenetic analysis of recovered antibody heavy- and light-chain variable regions was performed using the neighbor-joining algorithm (Jukes cantor model) and illustrated as circular trees