Table 2.
Comparison between demographic features and treatments received in H3 K27M-mutant tumors (N = 18) and wild type (N = 105). Values are median ± SEM
| H3 K27M WT | H3 K27M-mutant | P value | |
|---|---|---|---|
| Age | 53.1 ± 16.7 years | 45.1 ± 12.8 years | 0.51 |
| Sex (female) | 42/102 (41%) | 10/18 (56%) | 0.28 |
| CE on MRI | 80/96 (83%) | 15/18 (83%) | 0.58 |
| Treatment | 0.18 | ||
| Observation | 30 (29%) | 6 (33%) | |
| Radiation alone | 12 (11%) | – | |
| Chemoradiation | 47 (45%) | 11 (61%) | |
| Chemotherapy alone | 2 (2%) | – | |
| Unknown | 13 (12%) | 1 (6%) | |
| RT received | 61/92 (66%) | 11/17 (65%) | 0.77 |
| RT dose | 54.2 ± 1 Gy | 54 ± 1.8 Gy | 0.29 |
| Extent of surgery | 0.92 | ||
| Biopsy | 78 (64%) | 12 (67%) | |
| Subtotal resection | 33 (27%) | 4 (22%) | |
| Gross total resection | 10 (8%) | 1 (6%) | |
| Unknown | 2 (2%) | – |