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. 2019 Apr 24;9:6497. doi: 10.1038/s41598-019-42880-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of mammary tumors and tumor removal on nyctohemeral inflammatory gene expression in the brain. Mean ± SEM gene expression as assessed by RT²PCR arrays of brain (combined frontal cortex and hippocampus) (A) Myd88, (B) Cd4, (C) Tlr9, (D) Cd38, (E) C3, (F) Ly96 (n = 3–4/group). *p < 0.05 relative to control group at the same time point; ^&p < 0.05 relative to the other groups at the same time point by one-way ANOVA; ^#p < 0.05 relative to the same treatment during the light phase by two-way ANOVA and/or two-tailed Student’s t-test (day versus night).