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. 2019 Apr 24;9:6490. doi: 10.1038/s41598-019-43021-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of TF combinations that induce E phenotype in fibroblasts. (A) Identification of indispensable factor(s) for CDH1 induction in HNDFs, using an all-minus-one screening approach. Quantitative RT-PCR (RT-qPCR) was performed to quantify CDH1 expression 7 days after transduction of the indicated factors in HNDF. (B) Statistics analysis of CDH1 induction by combination of OVOL2 with HNF1A, TP63 or KLF4. Results are presented as means ± S.D. of three biological replicates. ^**p < 0.01 (C) OVOL2-plus-one factor screening was performed to identify the cooperative partners of OVOL2 in inducing CDH1 expression in HNDF.