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. 2019 Apr 24;9:6490. doi: 10.1038/s41598-019-43021-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enhanced chromatin accessibility changes by OVOL2 combined with lineage factors. (A) Genome browser view of ATAC-seq signals at the CDH1 and VIM loci. Promoter and potential enhancer regions that showed enhanced changes by a combination of TK + OVOL2 are highlighted in red and blue, respectively. Roadmap annotation of genomic regions (promoters and enhancers for the indicated cell types) is shown at the bottom. (B) A box plot showing Z-scores for expression (CAGE, top) or chromatin accessibility (ATAC, bottom) in E, M, K, and F genes, respectively. p-values were calculated through comparison with control samples. ^*p < 0.01, ^**p < 0.001, ^***p < 0.0001, ^****p < 0.00001.