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. 2019 Apr 18;10:381. doi: 10.3389/fneur.2019.00381

Figure 3.

Figure 3

The effects of CTs on the MAPK signaling pathways in neurons in OGD/R-injured NVU model. (A) Representative Western blots showing the levels of p-ERK1/2, p-JNK, p-p38, t-ERK1/2, t-JNK, and t-p38 in neurons. (B) Relative density refers to the ratio of p-ERK1/2 to t-ERK1/2, p-JNK to t-JNK and p-p38 to t-p38 (n = 4). The semiquantitative analyses suggested that CTs pre-treatment obviously reduced the phosphorylation of ERK1/2, JNK and p38 in OGD/R injury neurons, thus regulated cell apoptosis. Data are presented as the mean ± SD. **P < 0.01 vs. Control group; #P < 0.05, ##P < 0.01 vs. OGD2h/R24h group. ERK1/2, extracellular regulated protein kinases1/2; JNK, c-Jun N-terminal kinase; p38, p38 mitogen-activated protein kinases; CTs, cryptotanshinone.