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. 2019 Apr 18;10:381. doi: 10.3389/fneur.2019.00381

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Copyright © 2019 Zhao, Zheng, Yang, Fan, Zhu, Liu, Wu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CTs improved the BBB function in OGD/R-injured NVU model. (A,B) The numbers of survival BMECs and astrocytes were detected by trypan blue stain.The values were expressed as cells/cm² (n = 4). (C) TEER value was measured using a Millicell ERS-2 Voltohmmeter. The values were calculated according to the corresponding formula, and were expressed as Ω × cm² (n = 4). (D) Pe of SF was calculated according to the corresponding methods. Pe were expressed as × 10⁻⁶cm/s (n = 4). The detection results showed CTs had an effect of protecting BBB function from OGD/R injury. Data are presented as the mean ± SD. ^**P < 0.01 vs. Control group; ^#P < 0.05, ^##P < 0.01 vs. OGD2h/R24h group. BMECs, brain microvascular endothelial cells; TEER, transepithelial electrical resistance; Pe, permeability coefficient; SF, sodium fluorescein; CTs, cryptotanshinone.