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. 2019 Apr 18;10:381. doi: 10.3389/fneur.2019.00381

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Copyright © 2019 Zhao, Zheng, Yang, Fan, Zhu, Liu, Wu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of CTs on tight junction proteins and matrix metalloproteinase in BMECs in OGD/R-injured NVU model. (A) Representative Western blots showing the levels of ZO-1, Claudin-5, and Occludin in BMECs. (B) Relative density refers to the ratio of ZO-1, Claudin-5, and Occludin to β-actin. (C) Representative Western blots showing the levels of MMP-2 and MMP-9 in BMECs. (D) Relative density refers to the ratio of MMP-2 and MMP-9 to β-actin (n = 4). The semiquantitative analyses suggested CTs upregulated the expression of tight junction proteins by downregulating the expression of MMP-9 in OGD/R injury BMECs. Data are presented as the mean ± SD. ^**P < 0.01 vs. Control group; ^#P < 0.05, ^##P < 0.01 vs. OGD2h/R24h group. BMECs, brain microvascular endothelial cells; ZO-1, Zonula occludens-1; MMP-2, matrix metalloproteinase-2; MMP-9, matrix metalloproteinase-9; CTs, cryptotanshinone.