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. 2019 Apr 18;10:395. doi: 10.3389/fphys.2019.00395

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Copyright © 2019 Mahon, Ciarlone, Roney and Swift.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical representation of experimental design. The experiment consisted of a surgical epoch and four subsequent experimental periods. Baseline Monitoring (30 min of baseline monitoring; FiO₂ = 0.21); Drug Baseline [60 min of baseline monitoring after VEH or 5-HMF (20 or 40 mg/kg) administration; FiO₂ = 0.21]; Hypoxia Exposure (120 min of severe hypoxia exposure while sedated; FiO₂ = 0.10); Recovery (30 min of recovery post-hypoxia; FiO₂ = 0.21). ABG, arterial blood gas; VBG, venous blood gas; FiO₂, Fraction of Inspired Oxygen.