Table 1.
Effect of 5-HMF on oxyhemoglobin affinity (P50) during normoxia and hypoxia exposures in swine.
| Treatment | Time (FiO2) |
||||
|---|---|---|---|---|---|
| 30 (0.21) | 90 (0.21) | 150 (0.10) | 210 (0.10) | 240 (0.21) | |
| VEH | 43.05 ± 2.03 | 39.48 ± 4.85 | 42.00 ± 4.02 | 39.47 ± 3.44 | 40.97 ± 4.83 |
| 5-HMF-20 | 43.48 ± 3.23 | 42.43 ± 1.31 | 38.08 ± 8.26 | 23.47 ± 5.52#† | 22.18 ± 9.17#† |
| 5-HMF-40 | 41.10 ± 3.23 | 36.20 ± 8.14 | 33.79 ± 9.02#‡ | 28.47 ± 11.76#† | 24.23 ± 12.16#† |
Values in mmHg. Groups: VEH (100 ml NS), 5-HMF-20 (20 mg/kg 5HMF dissolved in 100 ml NS) and 5-HMF-40 (40mg/kg 5HMF dissolved in 100 ml NS). FiO2, Fraction of Inspired Oxygen. All values are mmHg mean ± SD. # vs. VEH (same time point; p ≤ 0.01); ‡ vs. Baseline (30 min measurement; p ≤ 0.05); vs. † Baseline (p ≤ 0.01).