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. 2019 Apr 18;9:298. doi: 10.3389/fonc.2019.00298

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Copyright © 2019 Li, Song, Liu, Li, Huang, Su, Mao, Wang, Mo and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of miR-214 on radiosensitivity of osteosarcoma in vitro and in vivo. (A) Clonogenic survival assays were performed in four osteosarcoma cell lines. An upward and rightward shift of survival curve indicated resistance to irradiation. (B) Treatment of miR-214 mimics decreased radiosensitivity of MG63 cells. (C) Treatment of anti-miR-214 increased sensitivity of U2OS cells to irradiation. (D) AntagomiR-214 decreased miR-214 expression in U2OS cells via qRT-PCR assay. (E) miR-214 depletion significantly inhibited the xenograft growth after combined treatment with irradiation, and representative photographs of xenografts from each group were shown. (F) Representative images of H&E staining and IHC analysis of PHLDA2 and Ki67 in xenograft tumors from miR-214 depleted-U2OS cells with irradiation (magnification: 100x for H&E staining, 200x for IHC). Black arrow represented necrosis. Data are presented as mean ± SD of three independent experiments. ^*P < 0.05.