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. 2019 Apr 18;6:78. doi: 10.3389/fmed.2019.00078

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Copyright © 2019 Spelta, Liverani, Peluso, Marinozzi, Urso, Guerrini and Naggi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Box-plots (median, first and third percentiles, range) of the main heparin attributes of the 33 heparin batches : N-sulfated glucosamine (GlcNS), 6-O-sulfated glucosamine (GlcNx,6S) and 2-O sulfated iduronic acid (IdoA2S) (A) molar ratio of sulfate to carboxylate ions ( ${SO}_{3}^{-}$ /COO⁻) (B) N-acetylated glucosamine (GlcNAc), GlcA-A^* or 3-O-sulfated-glucosamine (GlcNS,3S,6x), glucuronic acid linked to 3-O-sulfated-glucosamine (GlcA-GlcNS,3S,6x), N-desulfated glucosamine (GlcNH₂), galacturonic acid (GalA) and linkage region (LR) (C).