Table 2.

Epigenetic changes of CD8+ T cells in different autoimmune diseases.

Diseases	Involved organs/cells	Epigenetic changes	Species	Functions	References
GD	Thyroid	Hypermethylation of LCK, CD247, ZAP70, CD3D, CD3E, CD3G, CTLA4 and PDCD1, LAX1 and SLA2, and CD8A	Human	Disturbing the activation and regulation of CD8+ T cells	(123)
GD	Thyroid	Reduced H3K4me3 and H3K27ac of CD247, CD3E, CD3G, LCK, ZAP70, and CTLA4	Human	Involved in the activation of CD8+ T cells	(123)
GD	Thyroid	Reduced miRNA-200a_1 and miRNA-200a2*	Human	Assisting CD8+ T cells producing thyroid cell-specific antibodies	(122)
MS	CNS	Hypermethylation of MORN1		Not mentioned	(100)
MS	CNS	Increased miR-16, miR-155 and miR-142-3p	Human	Inhibiting Treg-suppressive activity	(124–126)
SSc	Skin	Hypomethylation of IFI44L, IFITM1, MX1, PARP9	Human	Activation of Wnt signaling	(127, 128)
T1D	β cells and pancreas	Increased miR-29b	Mice	Impairing the cytotoxicity of CD8+ T cells	(129)
SLE	Multi-organs	Hypomethylation of PRF	Human	Enhancing the cytotoxicity of CD8+ T cells	(56, 116)
SAA	Hematopoietic cells	Hypomethylation of LAT	Mice	Enhancing the cytotoxicity of CD8+ T cells	(130)
SAA	Hematopoietic cells	Increased histone H3 acetylation	Human	Enhancing the cytotoxicity of CD8+ T cells	(131)