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. 2019 Apr 18;13:391. doi: 10.3389/fnins.2019.00391

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Copyright © 2019 Yun, Reyes-Alcaraz, Lee, Yong, Choi, Ham, Sohn, Kim, Son, Kim, Kwon, Kim, Kim, Hwang and Seong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of intranasally administered SG2A on anxiety, depression-like, and feeding behaviors. Normal mice received various concentrations of SG2A (1, 3, and 10 μg/mouse). Anxiolytic effect of SG2A in the EPMT (A) and OFT (B). Antidepressant-like effect of SG2A in the TST (C) and FST (D). Cumulative changes in food intake (E) and body weight (F) during 7 consecutive administrations of SG2A. Data are presented as means ± SEMs; ^∗P < 0.05 and ^∗∗P < 0.01 vs. Veh. Numbers in parentheses indicate the numbers of animals used for each group.