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. 2019 Apr 18;9:288. doi: 10.3389/fonc.2019.00288

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Copyright © 2019 Ren, Huang, Dai, Xie, Zheng, Xie, Zheng, She, Zhou, Wang, Li, Fei, Jiang, Zhang, Su, Sweet-Cordero, Tran, Yang, Patel, Rolfo, Rocco, Cardona, Tuzi, Suter, Yang, Xu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lolliplots showing the distribution of germline and somatic variants in the top two genes, FLG (A,B) and MUC4 (C,D). For those germline variants that had >0.01 Chinese MAF, only those variants that were predicted to be deleterious by PROVEAN or damaging by SIFT are displayed (red star). The X-axis represents the exon and chromosome location. The Y-axis represents the occurrence of variants in GGNs (somatic) or patients (germline). The distribution of variants in AAH GGNs (upper panel) (A,C) was compared with that in other GGNs (bottom panel) (B,D).