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. 2019 Apr 18;10:294. doi: 10.3389/fphys.2019.00294

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Copyright © 2019 Gordleeva, Ermolaeva, Kastalskiy and Kazantsev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The dynamics of the tripartite synapse with astrocytic influence on synaptic transmission. (A) Time traces of membrane potentials of pre- (V_pre(t)) and post-synaptic (V_post(t)) neurons and calcium concentration (Ca²⁺(t)) in distal compartment of the astrocytic process without impact of astrocyte (γ₁ = γ₂ = 0). (B) Astrocyte-mediated potentiation of presynaptic release. Red line corresponds to the post-synaptic activity with astrocytic influence (γ₁ = 0.1). Black—without. Y(t) is the time trace of gliotransmitter concentration. (C) Astrocyte-mediated inhibition of presynaptic release. Red line corresponds to the postsynaptic activity without astrocytic influence (γ₁ = −0.4). (D) Astrocyte-mediated increasing of PSCs amplitudes. Red line corresponds to the postsynaptic activity with astrocytic influence (γ₂ = 1). λ = 9 Hz.