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. 2019 Apr 18;13:25. doi: 10.3389/fncir.2019.00025

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Copyright © 2019 Hu, Wu, Xu, Wang, Wang, Shen, Huang, Kan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CBF–FCS coupling changes of WD in basal ganglia, cerebellum, thalamus, and prefrontal cortex. (A) Scatter plots of mean GM level spatial correlations across voxels between CBF and FCS in HC (blue) and WD (red), respectively. (B) The GM regions of BG, CRB, THM, and PFC were extracted from AAL template. (C) The bar graph means CBF–FCS correlation across subjects in HC and WD. ^∗Significant differences between both groups (P < 0.05). BG, basal ganglia; CRB, cerebellum; THM, thalamus; PFC, prefrontal cortex; hcr, the relationship between FCS and CBF in healthy controls; wdr, the relationship between FCS and CBF in patients with Wilson’s disease.