Table 1.

Summary of scenarios evaluated in the clinical utility index analyses

Scenario	Key attributes	Minimal PP (utility = 0)	Target PP	Optimistic PP (utility = 1)	Weight
1	rPFS HR	0.73	0.70	0.65	0.6
	Diarrhea grade ≥ 3	20%	15%	10%	0.4
2	rPFS HR	0.73	0.70	0.65	0.6
	Diarrhea grade ≥ 3	20%	15%	10%	0.3
	Rash grade ≥ 3	15%	10%	5%	0.1
3	rPFS HR	0.73	0.70	0.65	0.6
	Diarrhea grade ≥ 2	45%	35%	25%	0.4
4	rPFS HR	0.73	0.70	0.65	0.6
	Diarrhea grade ≥ 2	45%	35%	25%	0.3
	Rash grade ≥ 2	18%	12%	6%	0.1

HR, hazard ratio; PP, product profile; rPFS, radiographic progression‐free survival.