Fig. 3.

Light micrographs of liver sections: Control group (A&B) showingnormal hepatic architecture and hepatic sinusoids are seen lined by endothelial cells and a Kupffer cell is seen. Aluminum oxide nanoparticles group(C &D) showing degenerative hydropicchanges and cellular infiltration in numerous hepatocytes, piecemeal necrosis, lyticnecrosis, congestion of sinusoidal blood vessels. Zinc oxide nanoparticles group (E&F) showing distended and hemorrhage in the portal veinlymphocytes aggregation, degenerated hepatocytes with pyknotic nuclei, hepatocyte vacuolization and cellular infiltration. Combination group (G&H) showing disturbed hepatic architecture in most of the lobule. Many of hepatocytes are vacuolated. While other are apoptotic, shrunken with pyknotic nuclei. Inflammatory cellular infiltration is evident in periportal areas and around the central veins. Widely dilated hepatic blood sinusoids are observed.(H & E stain. Mic.Mag. × 100 and ×400).