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. 2019 Apr 17;10:831. doi: 10.3389/fimmu.2019.00831

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Copyright © 2019 Wang, Yigit, van der Poel, Cuenca, Carroll, Herzog, Engel and Terhorst.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Administering αSLAMF3 to NP-OVA immunized B6 WT mice reduces B cell numbers and antibody responses. WT mice were immunized with NP-OVA in CFA along with 200 μg/mouse αSLAMF3 or isotype IgG1. Nine days later mice were euthanized and spleens were analyzed. (A) NP-specific antibody titers from serum of αSLAMF3 and isotype injected mice are as shown. (B) Total number of splenocytes from αSLAMF3 and isotype injected mice. (C) Representative Flow cytometry plots for GC staining: CD19⁺GL-7⁺FAS⁺ B cells (left), percentage and numbers of GC B cells (right). (D) Representative Flow cytometry plot showing gating strategy for TFH cells: CD4⁺PD-1⁺CXCR5⁺ (left panel) Percentages and numbers of TFH cells in spleen of αSLAMF3 and isotype injected mice (right panel). Data representative of three independent experiments. P-values are as shown.