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. 2019 Apr 18;10:702. doi: 10.3389/fimmu.2019.00702

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Copyright © 2019 Ryffel, Huang, Robinet, Panek, Couillin, Erard, Piotet, Le Bert, Mackowiak, Torres Arias, Dimier-Poisson and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T. gondii induced ileitis is attenuated in IL-33R/ST2 deficient mice. Reduced MPO activity, KC and neutrophils recruitment in the ileum of IL-33R KO mice (A–C), macroscopic signs of colon inflammation (D) and body weight loss (E) with enhanced survival of IL-33R/ST2 mice (F) associated with reduced severity of microscopic inflammation in the proximal ileum in the absence of ST2 (G) and semi-quantitative score of inflammation (H). Analysis at day 7 post-infection. Values are representative of two independent experiments expressed as mean ± SEM.