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Serum HMGB1 levels in PrxI- or PrxII-KO mice injected with LPS. (A, B) WT, PrxI–/–, or PrxII–/– mice were injected intraperitoneally with LPS (5 mg/kg), and blood samples were collected at 1 and 16 h, and measured concentration of TNFα (A) and HMGB1 (B), respectively. Means ± SD (n = 11 per group). **P < 0.01 versus wild type, t-test. NS, not significant.
