Comparison 2. High vs Moderate ICS Dose (All).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1 (% predicted)	4	130	Mean Difference (IV, Fixed, 95% CI)	5.32 [0.65, 9.99]
1.1 Adults	2	55	Mean Difference (IV, Fixed, 95% CI)	10.34 [2.45, 18.24]
1.2 Children	2	75	Mean Difference (IV, Fixed, 95% CI)	2.61 [‐3.18, 8.40]
2 Morning PEF (L/min)	2	63	Mean Difference (IV, Fixed, 95% CI)	7.91 [‐16.17, 32.00]
2.1 Adults	1	12	Mean Difference (IV, Fixed, 95% CI)	‐75.0 [‐228.70, 78.70]
2.2 Children	1	51	Mean Difference (IV, Fixed, 95% CI)	10.0 [‐14.39, 34.39]
3 Morning PEF (L/min) change from baseline	5	1117	Mean Difference (IV, Fixed, 95% CI)	5.72 [‐1.56, 13.00]
3.1 Adults	5	1117	Mean Difference (IV, Fixed, 95% CI)	5.72 [‐1.56, 13.00]
4 Diary Card Symptom Score (day) change baseline	2	794	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.06, 0.11]
4.1 Adults	2	794	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.06, 0.11]
5 Diary Card Symptom Score (night) change from baseline	2	800	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.06, 0.10]
5.1 Adults	2	800	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.06, 0.10]
6 Rescue Medications (puffs per day) change from baseline	2	788	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.39, 0.17]
6.1 Adults	2	788	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.39, 0.17]
7 Rescue Medications (puffs per night) change from baseline	2	788	Mean Difference (IV, Fixed, 95% CI)	‐0.03 [‐0.12, 0.05]
7.1 Adults	2	788	Mean Difference (IV, Fixed, 95% CI)	‐0.03 [‐0.12, 0.05]
8 Withdrawal Due to Adverse Event	2	301	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.14, 2.43]
8.1 Adults	2	301	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.14, 2.43]