Comparison 7. High vs Moderate ICS Dose (ICS Type).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1 (% predicted)	4		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 BUD	1	43	Mean Difference (IV, Fixed, 95% CI)	9.0 [‐2.90, 20.90]
1.2 FP	2	75	Mean Difference (IV, Fixed, 95% CI)	2.61 [‐3.18, 8.40]
1.3 BDP	1	12	Mean Difference (IV, Fixed, 95% CI)	11.40 [0.85, 21.95]
2 Morning PEF (L/min)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 BUD	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.2 FP	1	51	Mean Difference (IV, Fixed, 95% CI)	10.0 [‐14.39, 34.39]
2.3 BDP	1	12	Mean Difference (IV, Fixed, 95% CI)	‐75.0 [‐228.70, 78.70]
3 Morning PEF (L/min) change from baseline	5		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 BUD	4	950	Mean Difference (IV, Fixed, 95% CI)	8.26 [0.36, 16.16]
3.2 FP	1	167	Mean Difference (IV, Fixed, 95% CI)	‐8.75 [‐27.60, 10.10]
4 Diary Card Symptom Score (day) change baseline	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 BUD	2	794	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.06, 0.11]
4.2 FP	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Diary Card Symptom Score (night) change from baseline	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 BUD	2	800	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.06, 0.10]
5.2 FP	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Rescue Medications (puffs per day) change from baseline	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6.1 BUD	2	788	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.39, 0.17]
6.2 FP	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Rescue Medications (puffs per night) change from baseline	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
7.1 BUD	2	788	Mean Difference (IV, Fixed, 95% CI)	‐0.03 [‐0.12, 0.05]
7.2 FP	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Withdrawal Due to Adverse Event	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 BUD	1	134	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.04, 3.12]
8.2 FP	1	167	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.14, 6.69]