Comparison 8. High vs Low ICS Dose (ICS Type).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1	2		Std. Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 BUD	1	101	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.14 [‐0.53, 0.25]
1.2 FP	1	22	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.47 [‐1.32, 0.38]
2 Morning PEF (L/min)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 BUD	1	73	Mean Difference (IV, Fixed, 95% CI)	‐9.0 [‐53.35, 35.35]
2.2 FP	1	22	Mean Difference (IV, Fixed, 95% CI)	‐43.0 [‐116.66, 30.66]
3 Morning PEF (L/min) change from baseline	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 BUD	2	282	Mean Difference (IV, Fixed, 95% CI)	12.00 [‐1.50, 25.51]
3.2 FP	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Rescue Medications (no. of puffs)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 BUD	1	73	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐0.53, 0.73]
4.2 FP	1	22	Mean Difference (IV, Fixed, 95% CI)	‐1.8 [‐3.99, 0.39]
5 Withdrawal Due to Adverse Event	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 BUD	1	130	Risk Ratio (M‐H, Fixed, 95% CI)	0.24 [0.03, 2.05]
5.2 FP	1	165	Risk Ratio (M‐H, Fixed, 95% CI)	1.88 [0.17, 20.36]