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. 2004 Apr 19;2004(2):CD004109. doi: 10.1002/14651858.CD004109.pub2

Comparison 11. High vs Moderate ICS Dose (Device).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 FEV1 (% predicted) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1 DPI 1 43 Mean Difference (IV, Fixed, 95% CI) 9.0 [‐2.90, 20.90]
1.2 pMDI 1 24 Mean Difference (IV, Fixed, 95% CI) 1.0 [‐7.89, 9.89]
1.3 Nebuliser 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
2 Morning PEF(L/min) change from baseline 5   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1 DPI 4 1080 Mean Difference (IV, Fixed, 95% CI) 5.90 [‐1.56, 13.36]
2.2 pMDI 1 37 Mean Difference (IV, Fixed, 95% CI) 2.0 [‐31.96, 35.96]
2.3 Nebuliser 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Diary Card Symptom Score (day) change baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.1 DPI 2 794 Mean Difference (IV, Fixed, 95% CI) 0.02 [‐0.06, 0.11]
3.2 pMDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.3 Nebuliser 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Diary Card Symptom Score (night) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.1 DPI 2 800 Mean Difference (IV, Fixed, 95% CI) 0.02 [‐0.06, 0.10]
4.2 pMDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.3 Nebuliser 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Rescue Medications (puffs per day) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1 DPI 2 788 Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.39, 0.17]
5.2 pMDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.3 Nebuliser 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Rescue Medications (puffs per night) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1 DPI 2 788 Mean Difference (IV, Fixed, 95% CI) ‐0.03 [‐0.12, 0.05]
6.2 pMDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.3 Nebuliser 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Withdrawal Due to Adverse Event 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
7.1 DPI 2 301 Risk Ratio (M‐H, Fixed, 95% CI) 0.59 [0.14, 2.43]
7.2 pMDI 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.3 Nebuliser 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]