1 FEV1 change from baseline |
5 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
1.1 DPI |
2 |
84 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.37 [‐0.06, 0.81] |
1.2 pMDI |
3 |
452 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.07 [‐0.12, 0.25] |
1.3 Nebuliser |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
2 Morning PEF (L/min) change baseline |
5 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
2.1 DPI |
2 |
126 |
Mean Difference (IV, Fixed, 95% CI) |
10.54 [‐5.86, 26.95] |
2.2 pMDI |
3 |
285 |
Mean Difference (IV, Fixed, 95% CI) |
11.46 [‐0.75, 23.68] |
2.3 Nebuliser |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
3 Evening PEF (L/min) change from baseline |
3 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
3.1 DPI |
1 |
111 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐18.81, 18.81] |
3.2 pMDI |
2 |
130 |
Mean Difference (IV, Fixed, 95% CI) |
6.22 [‐6.36, 18.80] |
3.3 Nebuliser |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
4 PEF Diurnal Variation change from baseline |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
4.1 DPI |
2 |
126 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.28 [‐0.63, 0.07] |
4.2 pMDI |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
4.3 Nebuliser |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
5 Symptom Score change baseline |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
5.1 DPI |
1 |
15 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.70 [‐1.26, ‐0.14] |
5.2 pMDI |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
0.03 [‐0.15, 0.21] |
5.3 Nebuliser |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
6 Symptom (Night Waking) change from baseline |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
6.1 DPI |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
6.2 pMDI |
3 |
285 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.29 [‐0.53, ‐0.06] |
6.3 Nebuliser |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7 Rescue Medications (no. of puffs) change baseline |
4 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
7.1 DPI |
1 |
15 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.4 [‐1.23, 0.43] |
7.2 pMDI |
3 |
452 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.28 [‐1.24, 0.67] |
7.3 Nebuliser |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8 Withdrawal due to Adverse Event |
3 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
8.1 DPI |
1 |
130 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.71 [0.16, 3.03] |
8.2 pMDI |
2 |
393 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.26 [0.40, 4.00] |
8.3 Nebuliser |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9 Adverse Events |
4 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
9.1 DPI |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9.2 pMDI |
4 |
523 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.93, 1.17] |
9.3 Nebuliser |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10 Oral Candidiasis |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
10.1 DPI |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10.2 pMDI |
2 |
311 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.90 [0.34, 2.39] |
10.3 Nebuliser |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
11 Exacerbations |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
11.1 DPI |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
11.2 pMDI |
2 |
393 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.82 [0.47, 1.43] |
11.3 Nebuliser |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
12 Plasma Cortisol below reference range |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
12.1 DPI |
1 |
162 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.49 [0.13, 1.88] |
12.2 pMDI |
1 |
237 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.68 [0.29, 1.61] |
12.3 Nebuliser |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |