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. 2004 Apr 19;2004(2):CD004109. doi: 10.1002/14651858.CD004109.pub2

Comparison 14. Step down vs constant (Duration).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Morning PEF (L/min) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1 < = 12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.2 > 12 weeks 2 124 Mean Difference (IV, Fixed, 95% CI) ‐0.91 [‐26.13, 24.30]
2 Morning PEF (L/min) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1 < = 12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.2 > 12 weeks 2 643 Mean Difference (IV, Fixed, 95% CI) 0.83 [‐8.60, 10.26]
3 Diary Card Symptom Score (Day) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.1 < = 12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.2 > 12 weeks 2 647 Mean Difference (IV, Fixed, 95% CI) ‐0.07 [‐0.16, 0.03]
4 Diary Card Symptom Score (Night) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.1 < = 12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 > 12 weeks 2 645 Mean Difference (IV, Fixed, 95% CI) 0.06 [‐0.04, 0.15]
5 Rescue Medications (puffs per day) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1 < = 12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 > 12 weeks 2 643 Mean Difference (IV, Fixed, 95% CI) ‐0.18 [‐0.45, 0.08]
6 Rescue Medications (puffs per night) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1 < = 12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.2 > 12 weeks 2 643 Mean Difference (IV, Fixed, 95% CI) ‐0.04 [‐0.13, 0.05]
7 Withdrawal due to adverse event 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
7.1 < = 12 weeks 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 > 12 weeks 2 850 Risk Ratio (M‐H, Fixed, 95% CI) 1.54 [0.73, 3.24]
8 Proportion Achieving Asthma Control 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
8.1 < = 12 weeks 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 > 12 weeks 2 366 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.87, 1.16]